ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM
By: Sharma, Saruchi
.
Contributor(s): Vaneet Kumar.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(4).Description: 98-103p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
This study involves the synthesis of
Gum tragacanth
(gt) based interpenetrating polymer network (ipn) a
nd its utilization for sustained
release of anti-ulcerative drug i.e. pantoprazole s
odium.
Methods:
IPN was synthesized from Gum tragacanth, polyacryli
c acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in
distilled water. Further, acryamide
(aam) and methylmethacrylate (mma) was added and th
en kept for overnight. Later on, lipase and glutara
ldehyde were added. Homopolymers and
the unreacted monomers were removed using acetone.
Synthesized IPN was dried at 50 °C for further stud
y.
Synthesized ipn was swelled in water and the drug w
as added to it. The drug was entrapped in the pores
of the synthesized ipn and then drug
release behavior was studied using uv-vis spectroph
otometer.
Results:
Gt,
paa and mma based crosslinked IPN were synthesized
using lipase-glutaraldehyde as initiator-crosslinke
r system. The synthesized IPN
was pH sensitive and possessed the desired swelling
capacity required for the controlled and systematic
liberation of pantoprazole sodium at 37 °C.
The kinetic of drug release was studied and found t
hat lateral diffusion (D
L
) of drug was higher as compared to the initial dif
fusion (D
I
). The
prepared IPN can be used as prospective carrier for
prolonged drug delivery.
Conclusion:
A novel pH sensitive and colon targeted IPN was synt
hesized. It acts as an effective device for the con
trolled release of drug
pantoprazole sodium.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020916 |
Objective:
This study involves the synthesis of
Gum tragacanth
(gt) based interpenetrating polymer network (ipn) a
nd its utilization for sustained
release of anti-ulcerative drug i.e. pantoprazole s
odium.
Methods:
IPN was synthesized from Gum tragacanth, polyacryli
c acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in
distilled water. Further, acryamide
(aam) and methylmethacrylate (mma) was added and th
en kept for overnight. Later on, lipase and glutara
ldehyde were added. Homopolymers and
the unreacted monomers were removed using acetone.
Synthesized IPN was dried at 50 °C for further stud
y.
Synthesized ipn was swelled in water and the drug w
as added to it. The drug was entrapped in the pores
of the synthesized ipn and then drug
release behavior was studied using uv-vis spectroph
otometer.
Results:
Gt,
paa and mma based crosslinked IPN were synthesized
using lipase-glutaraldehyde as initiator-crosslinke
r system. The synthesized IPN
was pH sensitive and possessed the desired swelling
capacity required for the controlled and systematic
liberation of pantoprazole sodium at 37 °C.
The kinetic of drug release was studied and found t
hat lateral diffusion (D
L
) of drug was higher as compared to the initial dif
fusion (D
I
). The
prepared IPN can be used as prospective carrier for
prolonged drug delivery.
Conclusion:
A novel pH sensitive and colon targeted IPN was synt
hesized. It acts as an effective device for the con
trolled release of drug
pantoprazole sodium.
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